FORMULATION AND PHYSICAL STABILITY TEST OF LIP BALM PREPARATION OF MANGOSTEEN PEEL EXTRACT  (GARCINIA MANGOSTANA L.)

Nurrahmatia  Botutihe

doi:10.47918/jhts.v4i4.1617

Nurrahmatia Botutihe Universitas Bina Mandiri Gorontalo

DOI: https://doi.org/10.47918/jhts.v4i4.1617

Keywords: Mangosteen peel, Lip balm and lips

Abstract

The skin of mangosteen fruit (Garcinia mangostana) contains tannin and flavonoid compounds that are antioxidants and able to absorb UV rays. This study aims to determine the effect of lip balm preparation formulation on physical stability using mangosteen peel extract as a lip moisturizer.

The method used in this study is a laboratory experimental method which includes the extraction stage of mangosteen fruit peel with 96% ethanol solvent, with a concentration of 10%, 15% extract, 20% extract. Evaluation of lip balm preparations includes examination of stability, organoleptic, homogeneity, pH, adhesion, viscosity and melting point.

The results showed that the preparation of lip balm mangosteen peel extract (Garcinia mangostana) has a brown color, a distinctive citrus aroma, and a soft texture that is easy to smear. It has a melting point range of 50-70̊°C and a Ph range between 4.5-6.5. There are no changes in color, aroma, and texture on organoleptic tests during the storage period. Lip balm preparations also have a homogeneous composition. Based on the results of statistical tests, it can be concluded that there is an influence of extract concentration in formulations I, II, and III on the physical stability of the preparation. Based on the results obtained in cycling tests both before and after cycling tests in F1, F2 and F3 have good and stable physical stability in accordance with existing libraries.

References

1. Based on the results of the study, it can be concluded that there is no difference in the physical stability of formulations I, II, and III. The results of statistical analysis showed that the significance value of P>0.05 for pH test parameters (1.0 > 0.05), adhesion test (0.793 > 0.05), viscosity test (0.233 > 0.05), and melting point test (1.000 > 0.05).
2. Based on the results obtained in cycling tests both before and after cycling tests in F1, F2 and F3 have good and stable physical stability of preparations.
3. Based on the results of the physical stability test, the best formula is known to be F3 with an extract concentration of 20% and is proven by the results of the post hoc duncan test which can be seen from the pH test values F1 7.17, F2 12.83 and F3 19.00, adhesion test values F1 7.17, F2 12.83 and F3 19.00 and viscosity test values F1 22050, F2 24126.00 and F3 26242.83.

REFERENCES
[1] Abadi, H., Hanum, S. F., & Buulolo, I. A. (2020). Formulasi dan Uji Efektivitas Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) sebagai Pelembab Bibir. Jurnal Dunia Farmasi.
[2] Adikari, S. B., & Sharma, A. (2018). Marketing Pattern Of Rubber Plantation In Tripura. International Journal Of Current Microbiology And Applied Sciences.
[3] Agustina, Y. D., & Herliningsih. (2019). Formulasi Sediaan Lip Balm Dari Minyak Zaitun (Olive oil) Sebagai Emolien Dan Penambahan Buah Ceri (Prunus avium) Sebagai Pewarna Alami. Journal of Herbs and Farmacological.
[4] Akib, N. I., Nafisah, A., Adjeng, T., Lakasa, R. P., Suryani, S., Halimahtussaddiyah, R., Sartina, A., Armadany, F. I., & Kendari, M., (2020). Stabiltas Fisik Sediaan Tonik Rambut Kombinasi Ekstrak Etanol Rimpang Lengkuas (Alpinia galanga L.) dengan Filtrat Daun Lidah Buaya (Aloe vera L.) (Physical Stability of Hair Tonic Contain Ethanol Extract Galangal (Alpinia galanga L.) Rizome and. Farmauho : Jurnal Farmasi, Sains, dan Kesehatan.
[5] Ambari Y, Nanda F, Hapsari D, Ningsih AW, Nurrosyidah IH, Sinaga B. Studi Formulasi Sediaan Lip Balm Ekstrak Kayu Secang (Caesalpinia sappan L.) dengan Variasi Beeswax. J Islam Pharm (2020).
[6] BPOM, (2019), Peraturan Badan Pengawas Obat Dan Makanan Nomor 32 Tahun 2019 Tentang Persyaratan Keamanan Dan Mutu Obat Tradisional Dengan Rahmat Tuhan Yang Maha Esa Kepala Badan Pengawas Obat Dan Makanan,BPOM, Jakarta.
[7] Dewi, Rosmala., Effionora Anwar.,Yunita K S., (2014). Uji Stabilitas Fisik Formula Krim yang Mengandung Ekstrak Kacang Kedelai (Glycine max). Fakultas Farmasi Universitas Indonesia, Depok.
[8] Felisia, I., (2016). Pengaruh Komposisi Minyak Jarak dan Lanolin sebagai Basis Terhadap Sifat Fisik dan Stabilitas LIpstik dengan Pewarna Ekstrak Kulit Buah Manggis (Garcinia mangostana L.).
[9] Hidayah, Ratna. (2018). Formulasi Dan Evaluasi Sifat Fisik Sediaan Lip Balm Dari Buah Pisang Raja (Musa sapientum). Program D-III Farmasi. Politeknik Harapan Bersama Tegal.
[10] Jessica, Rijai L, Arifian H. Optimalisasi Basis Untuk Formulasi Sediaan Lip Cream. (2018).
[11] Limanda, D., & dkk. (2019). Formulasi dan Evaluasi Stabilitas Fisik Sediaan Lip Balm Minyak Almond (Prunus amygdalus dulcis). Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN.
[12] Mardiana, G. N dan Safitri, C. I. N. H. (2020). “Formulasi dan Uji Aktivitas Sediaan Gel Shampoo Antiketombe Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Terhadap Candida albicans”. Seminar Nasional Pendidikan Biologi dan Saintek (SNPBS).
[13] Nurfitriyana, Yulikasari, D., Fajar. I.R.F., Hardiyanti, L. (2023). Formulasi sediaan Lipbalm Ekstrak Daun Tin (Vicus carica L.) dan Ubi Jalar Ungu (Ipomoea batatas I.lam). ISTA online Technologi Journal.
[14] Nurhasnawati, H., Sukarmi., Handayani, F. (2017). Perbandingan Metode Ekstraksi Maserasi dan Sokhletasi Terhadap Aktivitas Antioksidan Ekstrak Etanol Daun Jambu Bol (Syzygium malaccense L.). Jurnal Ilmiah Manuntung.
[15] Nursetiani A, Halimah E. Identifikasi Persentase Kelengkapan Resep Di Salah Satu Rumah Sakit Di Kota Bandung. Farmaka. (2020).
[16] Priyanti, Nadyana, H. E., Daniya, A. A., Partuti, T., Amalina, N. N., Rahmiaty, D., Yanti, W. F., & Annisa, N. (2021). Ekstrak Etanol Kulit Manggis Sebagai Masker Gel Peel Off Berantioksidan. Jurnal Kimia Mulawarman.
[17] Puspita, Weni., Puspasari, Heny., Shabrina, Ayu. (2021). Formulation and PHYSICAL Stability Test Spray Gel of Extract of Buas-buas Leaf (Premna aerratifolia L.). Jurnal Farmasi Indonesia.
[18] Puspitasari, A. D. (2019.). Evaluasi Karakteristik Fisika Kimia dan Nilai SPF Sediaan Gel Tabir Surya Ekstrak Etanol Daun Kersen (Muntingia caabura L.). Jurnal Pharmascience.
[19] Rai R, Shanmuga S, Srinivas C. Update on photoprotection. Indian J Dermatol. (2012).
[20] Rasyadi, Y., Fendi, S.T.J., Permatasari, S. (2022). Formulasi Sediaan Lip Balm Dari Ekstrak Kulit Buah Melinjo (Gnetum gnemon L.). Parapemikir : Jurnal Ilmiah Farmasi.
[21] Rinaldi, R., Fauziah, F., Adriani, A., Silviana, E., Ritazahara, R. (2020). Studi Formulasi Gel Ekstrak Etanol Daun Nangka (Artocarpus heteropyllus Lam. L) dengan Basis Na-CMC dan Karbopol. Jurnal Dunia Farmasi.
[22] Sahputri, D., & Riski. (2019). Formulasi Sediaan Lip Balm Ekstrak Lidah Buaya (Aloe vera.L).
[23] Sona, F.R., (2018). Formulasi Haer Tonic Ekstrak Lidah Buaya (Aloe Vera L) Dan Uji Aktivitas Pertumbuhan Rambut Pada Tikus Putih Jantan. Jurusan Farmasi. Fakultas Kedokteran dan Ilmu Kesehatan. Universitas Islam Neferi Maulana Malik Ibrahim. Malang.
[24] Wahyuni, E. D. (2018). Asuhan Kebidanan Nifas dan Menyusui. Jakarta: Kementrian Kesehatan RI.
[25] Yusuf, N.A., Hardianti, B., Lestari, I.A., Sapra, A. (2019). Formulasi dan Evaluasi Lip balm Liofilisat Buah Tomat (Solanum lycopersicum L.) sebagai Pelembap Bibi