FORMULATION AND EVALUATION KRIM WAJAH ANTIAGING BERBASIS OF PEGAGANG LEAF EXTRACT-BASED ANTIAGING FACE CREAM DAUN PEGAGANG ( CENTELLA ASIATICA )
Abstract
Penuaan Skin aging is proses a natural process that is accelerated by faktor external factors such as exposure sinar to ultraviolet rays and stres oxidative stress radikal from free radicals. To overcome this , the use bahan of natural ingredients with aktivitas antioxidant activity and stimulan collagen stimulants is a focus in the development kosmetik of antiaging cosmetics. Salah One tanaman of the potential plants is Centella asiatica, which contains senyawa active compounds such as asiaticoside, madecassoside, and asiatic acid. This study ini aims to formulate and evaluate krim wajah antiaging face cream based ekstrak on ethanolic daun extract of Centella asiatica leaf in three variasi concentration variations (1%, 3%, and 5%). Metode The research method yang used was experimental, involving proses the formulation process krim tipe emulsi of oil -in -water emulsion type cream, followed by testing parameter of physical parameters (color, odor, pH, viscosity, daya dispersion, and daya adhesion) and uji aktivitas antioxidant activity test using metode DPPH method and inhibition enzim of elastase and collagenase enzymes. Hasil The results showed that all formulas had stabilitas fisik good physical stability baik during penyimpanan 28 days of storage. The Formula with konsentrasi an extract concentration of 5% (F3) showed aktivitas antioksidan the highest antioxidant activity (IC₅₀: 48 ppm) and kemampuan the most effective ability to inhibit enzymes that destroy the structure of the skin. And Thus, formulasi krim berbasis Centella asiatica-based cream formulations have potensi great potential as antiaging herbal cosmetic preparations antiaging that are effective, safe, and worthy
References
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Az-Zahra, F. (2024). Optimization Sediaan Krim of sunscreen cream preparation Surya Ekstrak ethanol extract Rimpang of turmeric Rhizome (Curcuma longa L.) Using Asam Stearic Acid and Triethanolaim as Emulgators. University Of Jambi. https://repository.unja.ac.id/63822/.
Sion, I. N. K., & Kerta, N. (2009). Gotu kola (Centella asiatica) as an alternative prevention penyakit of infectious diseases in livestock. Buletin Veteriner Udayana Veterinary Bulletin, 1(2), 61-67. https://www.academia.edu/download/82627259/1385.pdf.
Budiarti, A. D. (2025). PENGARUH GEL EKSTRAK DAUN PEGAGAN (Centella asiatica) DAN AIR ALKALI SECARA ORAL TERHADAP EKSPRESI CD86 DAN INTERLEUKIN–6 (IL-6)(Study Eksperimental in vivo pada Tikus Jantan Galur Wistar model collagen loss yang diinduksi Sinar UVB). Universitas Islam Sultan Agung Islamic University Semarang. ihttp://repository.unissula.ac.id/id/eprint/39377.
Buhang, N. D., Puspita, G., & Arbie, S. (2021). FORMULATION AND EVALUATION OF BREAST MILK ETHANOL EXTRACT FRUIT MEAT (Psidium Guajava L.) BY USING VARIATIONS OF EMULGATOR CONCENTRATION. Journal of Health, Technology and Science (JHTS), 2(1), 59–69. https://journals.ubmg.ac.id/index.php/JHTS/article/view/271.
Darmawan, A. B. (2015). Anti-Aging secrets to look young at any age. Media Pressindo. https://bintangpusnas.perpusnas.go.id/konten/BK20168/anti-aging-rahasia-tampil-muda-di-segala-usia
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Hanistya, R. (2020). Pengaruh Penambahan SPACE-Peptide Terhadap Efektifitas, Stabilitas Fisik dan Iritabilitas Sediaan Gel Freeze Dried Amniotic Membrane Stem Cell-Metabolite Product Sebagai Antiaging. UNIVERSITAS AIRLANGGA UNIVERSITY. ihttps://repository.unair.ac.id/110562.
Lahmudin, R. R., Gani, S. K., & Dukalang, F. I. (2024). Evaluation of the relationship of knowledge of women Usia of productive age in the village of Bongo with the attitude of the use Krim Pemutih of harmful Whitening Face Cream Yang . Jurnal Promotif Preventive Promotive Journal, 7(6), 1364-1369. https://journal.unpacti.ac.id/index.php/JPP/article/view/1652.
Marfitania, T., Hidayani, T. R., Chiuman, L., Fachrial, E., & Marbun, N. V. M. D. (2024). SLOW AGING WITH TANAMAN INDONESIAN PLANTS: BUKTI SCIENTIFIC EVIDENCE. PUBLISH BUKU UNPRI PRESS ISBN, 1(2). ihttps://jurnal.unprimdn.ac.id/index.php/ISBN/article/view/5816.
Ningsih, Z. (2023). Uji potensi Antiaging Ekstrak Daun Pegagan (Centella Asiatica) secara In Vitro dan In Silico. Universitas Islam Negeri Maulana Malik Ibrahim State Islamic University. ihttp://etheses.uin-malang.ac.id/43848/.
Proklama, N. L. P. (2024). Kemampuan krim ekstrak daun teh hijau (camellia sinensis) sebagai anti kolagenase: studi in vitro dan in silico. Universitas Islam Negeri Maulana Malik Ibrahim State Islamic University. ihttp://etheses.uin-malang.ac.id/72271/.
Purmawanti, S. (2024). Effect Krim Ekstrak Daun of Gotu Kola (Centella Asiatica) leaf extract cream on Inhibisi MMP-1 inhibition and Peningkatan collagen enhancement ( experimental study in mice Yang Dipapar Sinar exposed to acute UVB rays ). Universitas Islam Sultan Agung Islamic University (Indonesia). Magister Biomedik_MBK2220010318_fullpdf.pdf
Son, K. D. A., Pradnyaswari, G. A. D., & Setyawan, E. I. (2022). Potensi Nanostructured Lipid Carrier (NLC) dengan zat aktif ekstrak herba Pegagan (Centella asiatica (L.) Urb.) sebagai sediaan topical gel anti-photoaging. Proceedings Workshop Dan Seminar Of The National Pharmacy Workshop And Seminar Farmasi, 1, 295-312. ihttps://ejournal1.unud.ac.id/index.php/wsnf/article/view/44.
Safitri, N. A., Puspita, O. E., & Yurina, V. (2014). Optimization formula sediaan krim of strawberry extract cream preparation formula stroberi (Fragaria x ananassa) as krim anti -aging cream. Majalah Health Magazine, 1(4), 235-246. https://majalahfk.ub.ac.id/index.php/mkfkub/article/view/46.
Saraf, M., Pandya, U., & Thakkar, A. (2014). Role of allelochemicals in plant growth promoting rhizobacteria for biocontrol of phytopathogens. Microbiological Research, 169(1), 18–29. https://www.sciencedirect.com/science/article/pii/S0944501313001535?via%3Dihub
Sondari, D., Irawadi, T. T., Setyaningsih, D., & Tursiloadi, S. (2016). Studi Preliminary study of the effect metode of extraction method on yield and kadar asiaticoside content of Centella asiatica (L) Urb. Jurnal Indonesian Journal Of Material Science Indonesia, 17(3), 124-130. http://jusami.batan.go.id
Supu, R. D. (2022). UTILIZATION TANAMAN OBAT OF FAMILY MEDICINAL PLANTS IN HEALTH IN MASYARAKAT OLUHUTA VILLAGE , ATONGGOLA DISTRICT . Journal of Hulonthalo Service Society (JHSS), 1(1), 75–82. https://journals.ubmg.ac.id/index.php/JHSS/article/view/1168.
Tahir, S. A., Puspita, G., & Dunggio, T. (2022). FORMULATION OF LIPBALM FROM SARI MEAT PAPAYA FRUIT (Carica papaya L.) AS A PREPARATION SUNBLOCK. Journal of Health, Technology and Science (JHTS), 3(3), 12–23. https://journals.ubmg.ac.id/index.php/JHTS/article/view/426.
Wahid, H., & Karim, S. F. (2022). Krim Antiaging cream from Ekstrak Kolagen waste collagen extract Sisik Ikan of milkfish scales (Chanos chanos). Publisher NEM. https://books.google.com/books/about/Krim_Antiaging_dari_Ekstrak_Kolagen_Limb.html?id=7dCjEAAAQBAJ
WIJAYA, S. C. (2023). UJI AKTIVITAS EMULGEL ANTI-AGING KOMBINASI EKSTRAK HERBA PEGAGAN (Centella asiatica L.) And DAUN moringa leaf (Moringa oleifera) through REGULASI antioxidant regulation by METODE DPPH (2, 2-diphenyl-1-Picrylhydrazyl)method. Universitas Mahasaraswati University Denpasar. http://eprints.unmas.ac.id/id/eprint/5224/1/R.63.Farmasi_Bab%20I-II.pdf.
Witti, L., & Endriyatno, N. C. (2024). Formulation And Uji Physical Test Krim Ekstrak Of Meniran Herb Extract Cream Meniran (Pyllanthus Niruri L.) With Variations Asam Of Stearic Acid And Triethanolamine. Jurnal Indonesian Journal Of Pharmaceutical Research Indonesia, 13(1), 23-31. ihttps://ejournal.stifar-riau.ac.id/index.php/jpfi/article/view/1854.
Yuwanda, A., Rahmawati, D., & Anjani, F. S. (2023). Formulation and evaluation Aktivitas of antioxidant activity in the preparation Krim of Face Cream from Ekstrak ethanol extract of Gotu Kola leaves Pegagan (Centella Asiatica L.). Journal of Pharmacy and Halal Studies, 1(1), 9–16. ihttps://journal.eduscience.co.id/index.php/JPHS/article/view/2.
Arbie, S., Sugihartini, N., & Wahyuningsih, I. (2021). Formulation cream m / a with varying concentrations ekstrak buah of papaya fruit extract (Carica papaya l.) Using an emulgator asam of stearic acid and triethanolamine. Media Pharmaceutical Media, 16(1), 97-104. https://core.ac.uk/download/pdf/322591398.pdf
Az-Zahra, F. (2024). Optimization Sediaan Krim of sunscreen cream preparation Surya Ekstrak ethanol extract Rimpang of turmeric Rhizome (Curcuma longa L.) Using Asam Stearic Acid and Triethanolaim as Emulgators. University Of Jambi. https://repository.unja.ac.id/63822/.
Sion, I. N. K., & Kerta, N. (2009). Gotu kola (Centella asiatica) as an alternative prevention penyakit of infectious diseases in livestock. Buletin Veteriner Udayana Veterinary Bulletin, 1(2), 61-67. https://www.academia.edu/download/82627259/1385.pdf.
Budiarti, A. D. (2025). PENGARUH GEL EKSTRAK DAUN PEGAGAN (Centella asiatica) DAN AIR ALKALI SECARA ORAL TERHADAP EKSPRESI CD86 DAN INTERLEUKIN–6 (IL-6)(Study Eksperimental in vivo pada Tikus Jantan Galur Wistar model collagen loss yang diinduksi Sinar UVB). Universitas Islam Sultan Agung Islamic University Semarang. ihttp://repository.unissula.ac.id/id/eprint/39377.
Buhang, N. D., Puspita, G., & Arbie, S. (2021). FORMULATION AND EVALUATION OF BREAST MILK ETHANOL EXTRACT FRUIT MEAT (Psidium Guajava L.) BY USING VARIATIONS OF EMULGATOR CONCENTRATION. Journal of Health, Technology and Science (JHTS), 2(1), 59–69. https://journals.ubmg.ac.id/index.php/JHTS/article/view/271.
Darmawan, A. B. (2015). Anti-Aging secrets to look young at any age. Media Pressindo. https://bintangpusnas.perpusnas.go.id/konten/BK20168/anti-aging-rahasia-tampil-muda-di-segala-usia
Febrianto, A., Dewi, I. A., Dodyk Pranowo, S. T. P., & Maligan, J. M. (n.d.). Biocosmetic Opportunities Biokosmetik Indonesia: Application Of Technology That Is Cheap And Environmentally Friendly. Penerbit Manners Publishers. https://adabstore.co.id
Guna, I. N. G. A., & Justiantara, P. S. (2023). The potential of Gotu Kola (Centella asiatica) as Pengobatan an Alzheimer's treatment. Proceedings Workshop Dan Seminar Of The National Pharmaceutical Workshop And Seminar Farmasi, 2, 277-288. https://ejournal1.unud.ac.id/index.php/wsnf/article/view/645.
Hanistya, R. (2020). Pengaruh Penambahan SPACE-Peptide Terhadap Efektifitas, Stabilitas Fisik dan Iritabilitas Sediaan Gel Freeze Dried Amniotic Membrane Stem Cell-Metabolite Product Sebagai Antiaging. UNIVERSITAS AIRLANGGA UNIVERSITY. ihttps://repository.unair.ac.id/110562.
Lahmudin, R. R., Gani, S. K., & Dukalang, F. I. (2024). Evaluation of the relationship of knowledge of women Usia of productive age in the village of Bongo with the attitude of the use Krim Pemutih of harmful Whitening Face Cream Yang . Jurnal Promotif Preventive Promotive Journal, 7(6), 1364-1369. https://journal.unpacti.ac.id/index.php/JPP/article/view/1652.
Marfitania, T., Hidayani, T. R., Chiuman, L., Fachrial, E., & Marbun, N. V. M. D. (2024). SLOW AGING WITH TANAMAN INDONESIAN PLANTS: BUKTI SCIENTIFIC EVIDENCE. PUBLISH BUKU UNPRI PRESS ISBN, 1(2). ihttps://jurnal.unprimdn.ac.id/index.php/ISBN/article/view/5816.
Ningsih, Z. (2023). Uji potensi Antiaging Ekstrak Daun Pegagan (Centella Asiatica) secara In Vitro dan In Silico. Universitas Islam Negeri Maulana Malik Ibrahim State Islamic University. ihttp://etheses.uin-malang.ac.id/43848/.
Proklama, N. L. P. (2024). Kemampuan krim ekstrak daun teh hijau (camellia sinensis) sebagai anti kolagenase: studi in vitro dan in silico. Universitas Islam Negeri Maulana Malik Ibrahim State Islamic University. ihttp://etheses.uin-malang.ac.id/72271/.
Purmawanti, S. (2024). Effect Krim Ekstrak Daun of Gotu Kola (Centella Asiatica) leaf extract cream on Inhibisi MMP-1 inhibition and Peningkatan collagen enhancement ( experimental study in mice Yang Dipapar Sinar exposed to acute UVB rays ). Universitas Islam Sultan Agung Islamic University (Indonesia). Magister Biomedik_MBK2220010318_fullpdf.pdf
Son, K. D. A., Pradnyaswari, G. A. D., & Setyawan, E. I. (2022). Potensi Nanostructured Lipid Carrier (NLC) dengan zat aktif ekstrak herba Pegagan (Centella asiatica (L.) Urb.) sebagai sediaan topical gel anti-photoaging. Proceedings Workshop Dan Seminar Of The National Pharmacy Workshop And Seminar Farmasi, 1, 295-312. ihttps://ejournal1.unud.ac.id/index.php/wsnf/article/view/44.
Safitri, N. A., Puspita, O. E., & Yurina, V. (2014). Optimization formula sediaan krim of strawberry extract cream preparation formula stroberi (Fragaria x ananassa) as krim anti -aging cream. Majalah Health Magazine, 1(4), 235-246. https://majalahfk.ub.ac.id/index.php/mkfkub/article/view/46.
Saraf, M., Pandya, U., & Thakkar, A. (2014). Role of allelochemicals in plant growth promoting rhizobacteria for biocontrol of phytopathogens. Microbiological Research, 169(1), 18–29. https://www.sciencedirect.com/science/article/pii/S0944501313001535?via%3Dihub
Sondari, D., Irawadi, T. T., Setyaningsih, D., & Tursiloadi, S. (2016). Studi Preliminary study of the effect metode of extraction method on yield and kadar asiaticoside content of Centella asiatica (L) Urb. Jurnal Indonesian Journal Of Material Science Indonesia, 17(3), 124-130. http://jusami.batan.go.id
Supu, R. D. (2022). UTILIZATION TANAMAN OBAT OF FAMILY MEDICINAL PLANTS IN HEALTH IN MASYARAKAT OLUHUTA VILLAGE , ATONGGOLA DISTRICT . Journal of Hulonthalo Service Society (JHSS), 1(1), 75–82. https://journals.ubmg.ac.id/index.php/JHSS/article/view/1168.
Tahir, S. A., Puspita, G., & Dunggio, T. (2022). FORMULATION OF LIPBALM FROM SARI MEAT PAPAYA FRUIT (Carica papaya L.) AS A PREPARATION SUNBLOCK. Journal of Health, Technology and Science (JHTS), 3(3), 12–23. https://journals.ubmg.ac.id/index.php/JHTS/article/view/426.
Wahid, H., & Karim, S. F. (2022). Krim Antiaging cream from Ekstrak Kolagen waste collagen extract Sisik Ikan of milkfish scales (Chanos chanos). Publisher NEM. https://books.google.com/books/about/Krim_Antiaging_dari_Ekstrak_Kolagen_Limb.html?id=7dCjEAAAQBAJ
WIJAYA, S. C. (2023). UJI AKTIVITAS EMULGEL ANTI-AGING KOMBINASI EKSTRAK HERBA PEGAGAN (Centella asiatica L.) And DAUN moringa leaf (Moringa oleifera) through REGULASI antioxidant regulation by METODE DPPH (2, 2-diphenyl-1-Picrylhydrazyl)method. Universitas Mahasaraswati University Denpasar. http://eprints.unmas.ac.id/id/eprint/5224/1/R.63.Farmasi_Bab%20I-II.pdf.
Witti, L., & Endriyatno, N. C. (2024). Formulation And Uji Physical Test Krim Ekstrak Of Meniran Herb Extract Cream Meniran (Pyllanthus Niruri L.) With Variations Asam Of Stearic Acid And Triethanolamine. Jurnal Indonesian Journal Of Pharmaceutical Research Indonesia, 13(1), 23-31. ihttps://ejournal.stifar-riau.ac.id/index.php/jpfi/article/view/1854.
Yuwanda, A., Rahmawati, D., & Anjani, F. S. (2023). Formulation and evaluation Aktivitas of antioxidant activity in the preparation Krim of Face Cream from Ekstrak ethanol extract of Gotu Kola leaves Pegagan (Centella Asiatica L.). Journal of Pharmacy and Halal Studies, 1(1), 9–16. ihttps://journal.eduscience.co.id/index.php/JPHS/article/view/2.
Published
2025-09-24
How to Cite
HasanS., & Maulana T. S. (2025). FORMULATION AND EVALUATION KRIM WAJAH ANTIAGING BERBASIS OF PEGAGANG LEAF EXTRACT-BASED ANTIAGING FACE CREAM DAUN PEGAGANG ( CENTELLA ASIATICA ). Journal of Health, Technology and Science (JHTS), 6(3), 145-155. https://doi.org/10.47918/jhts.v6i3.2242
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Articles
Copyright (c) 2025 Safriandy Hasan, Tri Setiawati Maulana
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