EXT COMBINATION ACTIVITIES WHITE WOOD SHELF (Melaleucaleucadendra) AND HONEY AS NON-SPECIFIC IMUNOMODULATOR IN MALE WHITE RATS (Rattusnorvegicus)

Mita Kurniawati

doi:10.47918/jhts.v4i3.429

Mita Kurniawati Universitas Bina Mandiri Gorontalo

DOI: https://doi.org/10.47918/jhts.v4i3.429

Abstract

Mita Kurniawati, 2120192043. 2021. Aktivitas Kombinasi Ekstrak Kayu Putih (Melaleuca leucadendra) Dan Madu Sebagai Imunomodulator Non Spesifik Pada Tikus Putih Jantan (Rattus norvegicus). Skripsi, Pembimbing I: Dr. Laksmyn Kadir, M.Kes dan Pembimbing II: Apt. Moh. Taufik Ismullah, M.Farm. Program Studi S1- Farmasi, Fakultas Sains Teknologi dan Ilmu Kesehatan, Universitas Bina Mandiri Gorontalo.

Penelitian ini bertujuan untuk mengetahui kombinasi ekstrak daun kayu putih (Melaleuca leucadendra) dan madu dapat memberikan aktivitas imunomodulator non spesifik pada tikus putih jantan (Rattus norvegicus).

Metode dalam penelitian ini menggunakan quasy eksperimen dengan pendekatan pretest-posttest yang menggunakan kelompok uji dan kelompok pembanding (kontrol). Adapun kelompok tersebut yaitu: C1 (kontrol negatif), C2 (kontrol positif), dan C3 (kelompok uji).

Hasil penelitian menunjukkan bahwa tiga kelompok uji kombinasi ekstrak daun kayu putih (Melaleuca leucadendra) dan madu dapat meningkatkan kadar leukosit dalam darah yang berfungsi sebagai imunomodulator. Analisis data statistik Paired sample t-test dimana nilai signifikansi P ≤ 0,05 menunjukkan bahwa terdapat aktivitas antara kombinasi kayu putih (Melaleuca leucadendra) dan madu sehingga dapat meningkatkan kadar leukosit dalam darah yang berfungsi sebagai imunomodulator.

Kata kunci : Imunomodulator, Madu, Leukosit

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