Journal of Health, Technology and Science (JHTS)

IDENTIFICATION OF CORTICOSTEROID HARD DRUG CONTENT IN WHITENING COSMETIC PREPARATIONS CIRCULATING IN GORONTALO CITY

Saskia Pawala — 2023-12-15

This study aims to identify the corticosteroids in whitening cosmetic preparations circulating in Gorontalo City. The method used in this study was thin layer chromatography (TLC), with a qualitative approach and a descriptive (observational) type of research. The results showed that identification in the UV laboratory at a wavelength of 254 nm showed that from the 5 cream samples and 5 lotion samples for whitening cosmetic preparations tested, four of them were positive for the strong drug class of corticosteroid betamethasone valerate, namely with an Rf value on (cream sample E 0, 91), (lotion sample A 0, 91), (lotion sample B 1.0), and (lotion sample C 1.0) and have Rf values identical or similar to standard Rf values under the same chromatographic conditions.

THE ACTIVITY TEST OF BIDARA LEAF ETHANOL EXTRACT (ZIZIPHUS MAURITIANA) TOWARDS ESCHERICHIA COLI BACERIA

Andrheta Abd. Kadir — 2023-12-24

This research aims at investigating the antibacterial activity and optimum concentration of the ethanol extract of bidara leaves (Ziziphus mauritiana) against Escherichia coli bacteria. The method used in this research is a completely randomized design (CRD) consisting of 7 treatments and 4 replicates. The treatments are: P1 (negative control Aquades), P2 (10% concentration), P3 (12.5% concentration), P4 (15% concentration), P5 (17.5% concentration), P6 (20% concentration), and P7 (positive control Ciprofloxacin). The findings reveal that the concentration of ethanol extract of bidara leaves (Ziziphus mauritiana) has activity in inhibiting the growth of Escherichia coli bacteria. From the results of Kruskall-Wallis statistical analysis with a significant value of 0.003 or < 0.05, it appears that there is a dose of ethanol extract of bidara leaves (Ziziphus mauritiana) that affects the growth of Escherichia coli bacteria. After further testing (Duncan test), it was found that there was no significant difference between one concentration and another, so it can be said that the optimum concentration of bidara leaf ethanol extract treatment (Ziziphus mauritiana) in inhibiting the growth of Escherichia coli bacteria is at a concentration of 10%.

FORMULATION AND PHYSICAL STABILITY TEST OF LIP BALM PREPARATION OF MANGOSTEEN PEEL EXTRACT (GARCINIA MANGOSTANA L.)

Nurrahmatia Botutihe — 2024-01-18

The skin of mangosteen fruit (Garcinia mangostana) contains tannin and flavonoid compounds that are antioxidants and able to absorb UV rays. This study aims to determine the effect of lip balm preparation formulation on physical stability using mangosteen peel extract as a lip moisturizer.

The method used in this study is a laboratory experimental method which includes the extraction stage of mangosteen fruit peel with 96% ethanol solvent, with a concentration of 10%, 15% extract, 20% extract. Evaluation of lip balm preparations includes examination of stability, organoleptic, homogeneity, pH, adhesion, viscosity and melting point.

The results showed that the preparation of lip balm mangosteen peel extract (Garcinia mangostana) has a brown color, a distinctive citrus aroma, and a soft texture that is easy to smear. It has a melting point range of 50-70̊°C and a Ph range between 4.5-6.5. There are no changes in color, aroma, and texture on organoleptic tests during the storage period. Lip balm preparations also have a homogeneous composition. Based on the results of statistical tests, it can be concluded that there is an influence of extract concentration in formulations I, II, and III on the physical stability of the preparation. Based on the results obtained in cycling tests both before and after cycling tests in F1, F2 and F3 have good and stable physical stability in accordance with existing libraries.

ACTIVITY TEST OF LEMONGRASS LEAF EXTRACT (CYMBOPOGON CITRATUS) AGAINST STREPTOCOCCUS MUTANS BACTERIA AND ESCHERCHIA COLI

Nurul Sakinah — 2023-12-24

ABSTRACT

This study aims to determine the antibacterial activity of lemongrass leaf extract (Cymbopogon citratus) against Streptococcus mutans and Escherchia coli bacteria. This research method uses a Complete Randomized Design (RAL) consisting of 7 treatments and 4 repeats. The treatments are: P1 (negative control), P2 (10% concentration), P3 (20% concentration), P4 (30% concentration), P5 (40% concentration), P6 (50% concentration) and P7 (Amoxicillin positive control). The results showed that the concentration of lemongrass leaf extract (Cymbopogon citratus) has activity to inhibit the growth of Streptococcus mutans and Escherchia coli bacteria. The results of the statistical analysis of the Kruskall Wallis test showed a significant value of 0.008 or <0.05, so it can be said that there is a dose of lemongrass leaves (Cymbopogon citratus) against the growth of Streptococcus mutans bacteria. The processed data using the Kruskall Wallis test on Escherchia coli bacteria showed a significant value of 0.002 or <0.05, so it can be said that there is a dose of lemongrass leaves (Cymbopogon citratus) against Escherchia coli bacteria. Further tests (Duncan Test) found that there was no significant difference between one concentration and another, so it can be said that the optimum concentration of lemongrass leaf extract treatment (Cymbopogon citratus) in inhibiting the growth of Streptococcus mutans and Escherchia coli bacteria is at a concentration of 50%

THE EFFECT OF SOLVENT TYPE ON FLAVONOID LEVELS OF MORINGA LEAF EXTRACT (MORINGA OLEIFERA L.)

Putri Sakinah Munu — 2024-01-18

This study aims to determine the effect of the type of solvent on the levels of flavonoids in Moringa leaf extract (Moringa oleifera L.) and the differences in levels of flavonoids in each solvent. The method used in this study was a laboratory experimental method that included the extraction stage of Moringa leaves using three solvents, namely ethyl acetate, methanol, and 96% ethanol; the phytochemical screening test for the flavonoid compounds of Moringa leaf extract; and the flavonoid compounds test using UV-Vis Spectrophotometry. The results showed that there was an effect of the solvent type on the levels of flavonoid compounds in Moringa leaf extract (Moringa oleifera L.), and there were differences in the highest levels of flavonoids obtained in methanol extract of 2708.10 mg/L, 96% ethanol of 1890.24 mg/L, and ethyl acetate of 717.62 mg/L.

HEALTH SOCIAL SECURITY REFERRAL SYSTEM IN TOTO KABILA REGIONAL GENERAL HOSPITAL, BONE BOLANGO DISTRICT

Adnan Malaha — 2023-12-24

ABSTRACT

This research aims toknow how human resources are at the Toto Kabila Regional General Hospital, the availability of facilities and infrastructure for the implementation of the Health Social Security participant service system and know the Health Social Security verification system that exists at the Toto Kabila Regional General Hospital.

The method used in this study is the type of research thatis descriptive- Qualitative with a qualitative approach using data collection methods of observation, interviews and documentation

The results of this study were obtained in terms of sufficient human resources and no shortage of health workers, in terms of material (facilities and infrastructure) is not adequate becausethe lack of printing and computer facilities that sometimes have errors and in terms of the verification system already uses a bridging system that is fast and efficient in service. In the registration flow process by the patient, there were no errors during the service process, even so the deficiencies could still be handled properly by the Toto Kabila Hospital, Bone Bolango Regency, so that patients still get a good service process so that the health social security referral system is maximized.