EXT COMBINATION ACTIVITIES WHITE WOOD SHELF (Melaleucaleucadendra) AND HONEY AS NON-SPECIFIC IMUNOMODULATOR IN MALE WHITE RATS (Rattusnorvegicus)

Abstrak

Mita Kurniawati, 2120192043. 2021. The Combination of Eucalyptus Extract (Melaleuca leucadendra) and Honey as Non-Specific Immunomodulators in Male White Rats (Rattus norvegicus). Undergraduate Thesis, advisor I: Dr. Laksmyn Kadir, M.Kes., and advisor II: Apt. Moh. Taufik Ismullah, M.Farm. Bachelor of Pharmacy, Faculty of Science, Technology, and Health Sciences, Universitas Bina Mandiri Gorontalo.

This study aims to find out the combination of eucalyptus leaf extract (Melaleuca leucadendra) and honey that can provide non-specific Immunomodulators activity in male white rats (Rattus norvegicus).

The method in this study used quasi-experiments with a pretest-posttest approach that used test groups and comparison groups. The groups were: C1 (negative control), C2 (positive control), and C3 (test group).

The results showed that three test groups of a combination of eucalyptus leaf extract (Melaleuca leucadendra) and honey can increase the levels of leukocytes in the blood that serve as Immunomodulators. Analysis of paired sample t-test statistical data where the significance value of P ≤ 0.05 showed that there was activity between a combination of eucalyptus (Melaleuca leucadendra) and honey to increase the levels of leukocytes in the blood that function as immunomodulators.

Keywords: Immunomodulators, Honey, Leukocytes