EFFECTIVENESS OF JATROPHA CURCAS (Jatropha curcas) AS A BURN HEALING GEL PREPARATION

Nurul Pratiwi Sompah; Rini Daud Supu; Rifka Anggraini Anggai

doi:10.47918/jhts.v3i3.846

Nurul Pratiwi Sompah Universitas Bina Mandri Gorontalo
Rini Daud Supu
Rifka Anggraini Anggai

DOI: https://doi.org/10.47918/jhts.v3i3.846

Keywords: Keywords : jatropha sap, gel, burns

Abstract

This study aims to determine the formulation of jatropha curcas gel preparations as a burn healer, to determine the characteristics and physical properties of jatropha curcas gel preparations, and to determine theeffectiveness ofjatropha curcas gel as a burn healer.

The method in this study used an experimental method with five treatments. The treatments are: P1 (4% sap), P2 (8% sap), P3 (16% sap), P4 (Negative control), and P5 (Positive Control).

The results showed that the formulation of jatropha curcas gel positively contained saponin compounds that had a burn healing effect in male white rats (Rattus novergicus). Thejatropha curcas gel formulation has been shown to have a healing effect on burns of male white rats (Rattus novergicus) with a concentration of 16% providing the best healing effect with the occurrence of 100% healing (wound closure) on the third day, followed by a concentration of 8% healing (wound closure) 100% occurring on the sixth day, and a 4% concentration of 100% healing (wound closure) occurring on the ninth day.

References

[1] Armando dan Rochim. 2009. Memproduksi Minyak Atsiri Berkualitas. Cetakan I. Penerbit Penebar Swadaya. Jakarta.
[2] Ansel, H. C., 2008, Pengantar Bentuk Sediaan Farmasi, ed IV, Alih bahasa Ibrahim, F. Jakarta : UI Press.
[3] Bakar, A. 2012. Kedokteran Gigi Klinis. Yogyakarta: CV. Quantum Sinergis Media Kartika.
[4] Bakarbessy, E., Tumbel, F. T., Rehena, J. 2013. Beberapa Jenis Tanaman Obat Dan Penggunaannya Sebagai Antimalaria. Simbiosis, Jurnal Biologi Dan Pembelajarannya Program Studi Pendidikan Biologi Universitas Pattimura Ambon. Vol. 6, No. 2.
[5] Ditjen POM, Depkes RI. 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Departemen Kesehatan Republik Indonesia. Jakarta.
[6] Garg, A., D. Aggarwal, S. Garg, dan A. K. Sigla. (2002). Spreading of Semisolid Formulation. USA: Pharmaceutical Technology.
[7] Grace,Pierce A, neil R. Borley.2007.At a Glance Ilmu Bedah.edisi ketiga.Jakarta: Erlangga.
[8] Jackson D.M. The diagnosis of the depth of burning. Br J Surg 2018;40: 588-596
[9] Kawatu, C., Bodhi, W. & Mongi, J., 2013, Uji Efek Ekstrak Etanol Daun KucingKucingan (Acalypha indica L.) terhadap Kadar Gula Darah Tikus Putih Jantan Galur Wistar (Rattus novergicus). Pharmacon Jurnal Ilmiah Farmasi, 2(1), 81-87
[10] Salamah, N. & Hanifah.L., 2014. Uji Aktivitas Antioksidan Ekstrak Etanol Daun Suruhan (Paperomia pellucida ( L) H.B&K) dengan Metode Fosfolibdat. Prosiding SPOA XVI dan Muktamar XII PERHIPBA, pp.341-349.
[11] Tiwari R, Ausman LM, Agho KE. Determinant of Stunting and Severe Stunting Among Under-Fives: Evidance from the 2011 Nepal Demographic and Health Survey. BMC Pediatr. 2014;(1):1-15
[12] Wijaya, R. A. 2013. Formulasi Gel Ekstrak Lidah Buaya (Aloe vera) Sebagai Alternatif Penyembuh Luka Bakar. Semarang: Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Semarang
[13] Yalianita. 2019. "Activity Of Antifungal Ethanol Extract 50% And Ethanol 96% Leaf Henna Nail Lawsonia inermis L Against Trichophyton mentagrophytes”. Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup .19(1) : 12-19
[14] Yapa, KS 2009, Management of Burns in the Community, Wounds, United Kingdom, pp. 8-48, diakses 28 Agustus 2017
[15] Yarfati, K. Eriani, dan A. Damhoeri. 2011. The Potential of Jarak Cina (Jatropha multifida, L) Secretion in Healing New-Wounded Mice.Jurnal Natural. Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Syiah Kuala Press, Banda Aceh
[16] Zeniyanti A, Ratnawati H, Puradisastra S. 2009: 8(2): 132-138. Perbandingan Ozon, Getah Jarak Cina (Jatropha Multifida L.) dan Povidone iodine 10% Terhadap Waktu Penyembuhan Luka Pada Mencit Betina Galur Swiss Webster. Jurnal Kedokteran Maranatha
[17] Zainal Ch., Muntiaha, Pauliana V. Y yamlean, & Widya A. L. 2014. Uji Efektivitas Sediaan Krim Getah Jarak Cina (Jatropha multifida L.) untuk Pengobatan Luka Sayat yang Terinfeksi Bakteri Staphylococcus aureus pada Kelinci (Orytolagus cuniculus). Program Studi Farmasi FMIPA UNSRAT Manado. ISSN : 2302-2493.